Fremantle has lost young duo Sam Sturt and Heath Chapman for the remainder of the season.
Sturt injured his knee in the WAFL and has been sent in for surgery.
Chapman meanwhile suffered a shoulder injury in the Derby last week.
Teammates Ethan Hughes and Bailey Banfield are also set for stints on the sidelines.
Crosstown rivals West Coast continue to be cruelled by injuries as well.
Defender Liam Duggan will miss five weeks with a knee injury of his own.
The Eagles have 17 of their 2018 premiership side still on their list and 11 will be unavailable for this week’s clash with Hawthorn.